What is Mona Lisa Smile?

Professional education and early diagnosis of endometriosis in adolescence

Funded by the Erasmus+ Programme of the EU, Mona Lisa Smile develops a digital training (MOOCS) and a specific app, and addresses the needs of education and training of health professionals on endometriosis in adolescence, with the aim of reducing the diagnostic delay.

Endometriosis diagnostic delay is estimated to be around 7 years, despite the early symptoms onset

The diagnostic delay is probably due to an inadequate knowledge of the disease among health professionals, together with the peculiar aspects of this condition in adolescent patients.

The presence of endometriosis in the adolescent young woman was compared to a ‘Mona Lisa smile with a mysterious innocence. The complaints are common and elicit compassion, but do not stimulate a search for the cause.’ (Ivo Brosens 2013).

University of Bologna, where the project started

The University of Bologna is project coordinator, with the support of the U.O. Reproductive Gynecology and Pathophysiology - IRCCS Policlinico S. Orsola Bologna, Italy. The Project, conceived by Prof. Seracchioli, Drs. Simona Del Forno and Drs. Giulia Borghese, involves 5 European partners.



Prof. Renato Seracchioli
Prof. Renato Seracchioli

Full Professor of Gynecology and Obstetrics at the University of Bologna and director of the Gynecology and Physiopathology of Human Reproduction Unit of the Sant’Orsola Hospital (IT)

Prof. Enrico Zupi

He is a well-established expert in the management and treatment of endometriosis and adenomyosis, is a full professor of Ob/Gyn at the University of Siena, Italy, and owns the directorship of the Gynecological Unit in Siena

Prof. Lucia Lazzeri

She is an associate professor of Ob/Gyn at the University of Siena, Italy, she is known worldwide for her expertise in the diagnosis and management of endometriosis and adenomyosis

Prof. Lil Valentin

Professor Lil Valentin is a Professor in Obstetrics and Gynecology, Lund University, Sweden, since 2002 and she has more than 40 years of experience in the field of Obstetrics and Gynecology. Her major research interest is in Obstetric and Gynecologic Ultrasound, Gynecological Ultrasound and Doppler in particular

Prof. Ligita Jokubkiene

Associate Professor Dr. Ligita Jokubkiene, is Senior Consultant at the Department of Obstetrics and Gynecology at Skåne University Hospital in Malmö, Sweden. She is MD, PhD, Senior Consultant Skånes Universitetssjukhus, Department of Obstetrics and Gynecology

Dr. Simona Del Forno

She has been joining the Gynecology and Human Reproduction Physiopathology Unit of IRCCS Azienda Ospedaliero-Universitaria, Policlinico di Sant’Orsola, since 2016, with particular interest in endometriosis and pelvic pain, ultrasound in gynecology and low genital tract disease

Dr. Giulia Borghese

She has been joining the Gynecology and Human Reproduction Physiopatology Unit directed by Professor Seracchioli since 2018, focusing on endometriosis, pelvic pain and low genital tract disease. She is especially interested in studying and treating pelvic pain in young women

Dr. Emanuela Spagnolo

She is consultant gynecologist at La Paz University Hospital (Madrid, Spain), she is expert in pelvic surgery and laparoscopy, and in the comprehensive treatment of endometriosis

Prof. Alicia Hernandez Gutierrez

Prof Alicia Hernandez Gutierrez is the Chief of Gynaecology Department at La Paz University Hospital (Madrid, Spain) and associated Professor at Universidad Autónoma de Madrid

Dr. Cristina Redondo Guisasola

She is consultant gynecologist at La Paz University Hospital (Madrid, Spain) she is specialized in minimally invasive surgery and in the comprehensive treatment of endometriosis, both medical and surgical

Dr. Ana López Carrasco

She is Professor “ad honorem” of the Universidad Autónoma de Madrid, from the 2017 and Professor of the Master in Gynecological Endoscopic Surgery, Universidad Autónoma de Madrid (all editions)

Prof. Michelle Nisolle

President (at ULiege) and Head (at CHU Liege) of OBGYN Dpt in Belgium, her clinical activity focuses on endoscopic management of benign pathologies (esp. endometriosis)

Dr. Eugenia Degli Esposti

Dr. Degli Esposti has been part of the medical staff of the Gynecology and Human Reproduction Physiopathology Unit, directed by Professor Seracchioli since 2017, focusing on endometriosis, pelvic pain, and minimally invasive surgery.

Discover our expanded team

Worked with us: Sara Beltrami (Project Manager), Studio Talea (Brand identity), Studio But Maybe (Website design & development)

Relevant FAQ

How to join the project?

Fore more info please visit and Join the European Project Mona Lisa Smile!

When is the deadline to register for the MOOCS?

It is always possible to take part in the MOOCS, there's no deadline.

Am I entitled to receive a certificate?

Yes, when you have completed the MOOCS you can ask for an individual certificate.

Please visit:

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